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- Title
Targeting the PI3K/Akt cell survival pathway to induce cell death of HIV-1 infected macrophages with alkylphospholipid compounds.
- Authors
Lucas, Amanda; Kim, Yuri; Rivera-Pabon, Omayra; Chae, Sunju; Kim, Dong-Hyun; Kim, Baek
- Abstract
HIV-1 infected macrophages and microglia are long-lived viral reservoirs persistently producing viral progenies. HIV-1 infection extends the life span of macrophages by promoting the stress-induced activation of the PI3K/Akt cell survival pathway. Importantly, various cancers also display the PI3K/Akt activation for long-term cell survival and outgrowth, and Akt inhibitors have been extensively searched as anti-cancer agents. This led us to investigate whether Akt inhibitors could antagonize long-term survival and cytoprotective phenotype of HIV-1 infected macrophages.
- Publication
PloS one, 2010, Vol 5, Issue 9
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0013121