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- Title
A common variant in the telomerase RNA component is associated with short telomere length.
- Authors
Njajou, Omer T; Blackburn, Elizabeth H; Pawlikowska, Ludmila; Mangino, Massimo; Damcott, Coleen M; Kwok, Pui-Yan; Spector, Timothy D; Newman, Anne B; Harris, Tamara B; Cummings, Steven R; Cawthon, Richard M; Shuldiner, Alan R; Valdes, Ana M; Hsueh, Wen-Chi
- Abstract
Telomeres shorten as cells divide. This shortening is compensated by the enzyme telomerase. We evaluated the effect of common variants in the telomerase RNA component (TERC) gene on telomere length (TL) in the population-based Health Aging and Body Composition (Health ABC) Study and in two replication samples (the TwinsUK Study and the Amish Family Osteoporosis Study, AFOS).
- Publication
PloS one, 2010, Vol 5, Issue 9, pe13048
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0013048