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- Title
Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
- Authors
Hendrickson, Sher L; Lautenberger, James A; Chinn, Leslie Wei; Malasky, Michael; Sezgin, Efe; Kingsley, Lawrence A; Goedert, James J; Kirk, Gregory D; Gomperts, Edward D; Buchbinder, Susan P; Troyer, Jennifer L; O'Brien, Stephen J
- Abstract
The human mitochondrial genome includes only 13 coding genes while nuclear-encoded genes account for 99% of proteins responsible for mitochondrial morphology, redox regulation, and energetics. Mitochondrial pathogenesis occurs in HIV patients and genetically, mitochondrial DNA haplogroups with presumed functional differences have been associated with differential AIDS progression.
- Publication
PloS one, 2010, Vol 5, Issue 9, pe12862
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0012862