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- Title
Selective disruption of the cerebral neocortex in Alzheimer's disease.
- Authors
Desikan, Rahul S; Sabuncu, Mert R; Schmansky, Nicholas J; Reuter, Martin; Cabral, Howard J; Hess, Christopher P; Weiner, Michael W; Biffi, Alessandro; Anderson, Christopher D; Rosand, Jonathan; Salat, David H; Kemper, Thomas L; Dale, Anders M; Sperling, Reisa A; Fischl, Bruce; Alzheimer's Disease Neuroimaging Initiative
- Abstract
Alzheimer's disease (AD) and its transitional state mild cognitive impairment (MCI) are characterized by amyloid plaque and tau neurofibrillary tangle (NFT) deposition within the cerebral neocortex and neuronal loss within the hippocampal formation. However, the precise relationship between pathologic changes in neocortical regions and hippocampal atrophy is largely unknown.
- Publication
PloS one, 2010, Vol 5, Issue 9, pe12853
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0012853