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- Title
Loss of STOP protein impairs peripheral olfactory neurogenesis.
- Authors
Benardais, Karelle; Kasem, Basem; Couegnas, Alice; Samama, Brigitte; Fernandez, Sebastien; Schaeffer, Christiane; Antal, Maria-Cristina; Job, Didier; Schweitzer, Annie; Andrieux, Annie; Giersch, Anne; Nehlig, Astrid; Boehm, Nelly
- Abstract
STOP (Stable Tubulin-Only Polypeptide) null mice show behavioral deficits, impaired synaptic plasticity, decrease in synaptic vesicular pools and disturbances in dopaminergic transmission, and are considered a neurodevelopmental model of schizophrenia. Olfactory neurons highly express STOP protein and are continually generated throughout life. Experimentally-induced loss of olfactory neurons leads to epithelial regeneration within two months, providing a useful model to evaluate the role played by STOP protein in adult olfactory neurogenesis.
- Publication
PloS one, 2010, Vol 5, Issue 9, pe12753
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0012753