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- Title
Loss of c-Met disrupts gene expression program required for G2/M progression during liver regeneration in mice.
- Authors
Factor, Valentina M; Seo, Daekwan; Ishikawa, Tsuyoshi; Kaposi-Novak, Pal; Marquardt, Jens U; Andersen, Jesper B; Conner, Elizabeth A; Thorgeirsson, Snorri S
- Abstract
Previous work has established that HGF/c-Met signaling plays a pivotal role in regulating the onset of S phase following partial hepatectomy (PH). In this study, we used Met(fl/fl);Alb-Cre(+/-) conditional knockout mice to determine the effects of c-Met dysfunction in hepatocytes on kinetics of liver regeneration.
- Publication
PloS one, 2010, Vol 5, Issue 9
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0012739