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- Title
The unfolded protein response is not necessary for the G1/S transition, but it is required for chromosome maintenance in Saccharomyces cerevisiae.
- Authors
Henry, Kelsey A; Blank, Heidi M; Hoose, Scott A; Polymenis, Michael
- Abstract
The unfolded protein response (UPR) is a eukaryotic signaling pathway, from the endoplasmic reticulum (ER) to the nucleus. Protein misfolding in the ER triggers the UPR. Accumulating evidence links the UPR in diverse aspects of cellular homeostasis. The UPR responds to the overall protein synthesis capacity and metabolic fluxes of the cell. Because the coupling of metabolism with cell division governs when cells start dividing, here we examined the role of UPR signaling in the timing of initiation of cell division and cell cycle progression, in the yeast Saccharomyces cerevisiae.
- Publication
PloS one, 2010, Vol 5, Issue 9, pe12732
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0012732