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- Title
Akt deficiency attenuates muscle size and function but not the response to ActRIIB inhibition.
- Authors
Goncalves, Marcus D; Pistilli, Emidio E; Balduzzi, Anthony; Birnbaum, Morris J; Lachey, Jennifer; Khurana, Tejvir S; Ahima, Rexford S
- Abstract
Akt is a critical mediator of developmental skeletal muscle growth. Treatment with a soluble ActRIIB fusion protein (ActRIIB-mFc) increases skeletal muscle mass and strength by inhibiting myostatin and related peptides. Recent in vitro studies have suggested that Akt signaling is necessary for the ability of ActRIIB inhibition to induce muscle hypertrophy. Thus, we hypothesized that mice deficient in either Akt1 or Akt2 would not respond to in vivo inhibition of ActRIIB with ActRIIB-mFc treatment.
- Publication
PloS one, 2010, Vol 5, Issue 9, pe12707
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0012707