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- Title
Regulation of heparin-binding EGF-like growth factor by miR-212 and acquired cetuximab-resistance in head and neck squamous cell carcinoma.
- Authors
Hatakeyama, Hiromitsu; Cheng, Haixia; Wirth, Pamela; Counsell, Ashley; Marcrom, Samuel R; Wood, Carey Burton; Pohlmann, Paula R; Gilbert, Jill; Murphy, Barbara; Yarbrough, Wendell G; Wheeler, Deric L; Harari, Paul M; Guo, Yan; Shyr, Yu; Slebos, Robbert J; Chung, Christine H
- Abstract
We hypothesized that chronic inhibition of epidermal growth factor receptor (EGFR) by cetuximab, a monoclonal anti-EGFR antibody, induces up-regulation of its ligands resulting in resistance and that microRNAs (miRs) play an important role in the ligand regulation in head and neck squamous cell carcinoma (HNSCC).
- Publication
PloS one, 2010, Vol 5, Issue 9, pe12702
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0012702