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- Title
Amino-acid co-variation in HIV-1 Gag subtype C: HLA-mediated selection pressure and compensatory dynamics.
- Authors
Rolland, Morgane; Carlson, Jonathan M; Manocheewa, Siriphan; Swain, J Victor; Lanxon-Cookson, Erinn; Deng, Wenjie; Rousseau, Christine M; Raugi, Dana N; Learn, Gerald H; Maust, Brandon S; Coovadia, Hoosen; Ndung'u, Thumbi; Goulder, Philip J R; Walker, Bruce D; Brander, Christian; Heckerman, David E; Mullins, James I
- Abstract
Despite high potential for HIV-1 genetic variation, the emergence of some mutations is constrained by fitness costs, and may be associated with compensatory amino acid (AA) co-variation. To characterize the interplay between Cytotoxic T Lymphocyte (CTL)-mediated pressure and HIV-1 evolutionary pathways, we investigated AA co-variation in Gag sequences obtained from 449 South African individuals chronically infected with HIV-1 subtype C.
- Publication
PloS one, 2010, Vol 5, Issue 9
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0012463