We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis.
- Authors
Hov, Johannes R; Keitel, Verena; Laerdahl, Jon K; Spomer, Lina; Ellinghaus, Eva; ElSharawy, Abdou; Melum, Espen; Boberg, Kirsten M; Manke, Thomas; Balschun, Tobias; Schramm, Christoph; Bergquist, Annika; Weismüller, Tobias; Gotthardt, Daniel; Rust, Christian; Henckaerts, Liesbet; Onnie, Clive M; Weersma, Rinse K; Sterneck, Martina; Teufel, Andreas; Runz, Heiko; Stiehl, Adolf; Ponsioen, Cyriel Y; Wijmenga, Cisca; Vatn, Morten H; Stokkers, Pieter C F; Vermeire, Severine; Mathew, Christopher G; Lie, Benedicte A; Beuers, Ulrich; Manns, Michael P; Schreiber, Stefan; Schrumpf, Erik; Häussinger, Dieter; Franke, Andre; Karlsen, Tom H; IBSEN Study Group
- Abstract
TGR5, the G protein-coupled bile acid receptor 1 (GPBAR1), has been linked to inflammatory pathways as well as bile homeostasis, and could therefore be involved in primary sclerosing cholangitis (PSC) a chronic inflammatory bile duct disease. We aimed to extensively investigate TGR5 sequence variation in PSC, as well as functionally characterize detected variants.
- Publication
PloS one, 2010, Vol 5, Issue 8, pe12403
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0012403