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- Title
The protease inhibitor alpha-2-macroglobulin-like-1 is the p170 antigen recognized by paraneoplastic pemphigus autoantibodies in human.
- Authors
Schepens, Isabelle; Jaunin, Fabienne; Begre, Nadja; Läderach, Ursula; Marcus, Katrin; Hashimoto, Takashi; Favre, Bertrand; Borradori, Luca
- Abstract
Paraneoplastic pemphigus (PNP) is a devastating autoimmune blistering disease, involving mucocutaneous and internal organs, and associated with underlying neoplasms. PNP is characterized by the production of autoantibodies targeting proteins of the plakin and cadherin families involved in maintenance of cell architecture and tissue cohesion. Nevertheless, the identity of an antigen of Mr 170,000 (p170), thought to be critical in PNP pathogenesis, has remained unknown.
- Publication
PloS one, 2010, Vol 5, Issue 8, pe12250
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0012250