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- Title
A Genome-Wide Gene Function Prediction Resource for Drosophila melanogaster.
- Authors
Han Yan; Venkatesan, Kavitha; Beaver, John E.; Klitgord, Niels; Yildirim, Muhammed A.; Tong Hao; Hill, David E.; Cusick, Michael E.; Perrimon, Norbert; Roth, Frederick P.; Vidal, Marc
- Abstract
Predicting gene functions by integrating large-scale biological data remains a challenge for systems biology. Here we present a resource for Drosophila melanogaster gene function predictions. We trained function-specific classifiers to optimize the influence of different biological datasets for each functional category. Our model predicted GO terms and KEGG pathway memberships for Drosophila melanogaster genes with high accuracy, as affirmed by cross-validation, supporting literature evidence, and large-scale RNAi screens. The resulting resource of prioritized associations between Drosophila genes and their potential functions offers a guide for experimental investigations.
- Publication
PLoS ONE, 2010, Vol 5, Issue 8, p1
- ISSN
1932-6203
- Publication type
Academic Journal
- DOI
10.1371/journal.pone.0012139