We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The hemorrhagic coli pilus (HCP) of Escherichia coli O157:H7 is an inducer of proinflammatory cytokine secretion in intestinal epithelial cells.
- Authors
Ledesma, Maria A; Ochoa, Sara A; Cruz, Ariadnna; Rocha-Ramírez, Luz M; Mas-Oliva, Jaime; Eslava, Carlos A; Girón, Jorge A; Xicohtencatl-Cortes, Juan
- Abstract
Enterohemorrhagic Escherichia coli (EHEC) O157:H7, the causative agent of hemorrhagic colitis and the hemolytic uremic syndrome (HUS), produces long bundles of type IV pili (TFP) called hemorrhagic coli pili (HCP). HCP are capable of mediating several phenomena associated with pathogenicity: i) adherence to human and bovine epithelial cells; ii) invasion of epithelial cells; iii) hemagglutination of rabbit erythrocytes; iv) biofilm formation; v) twitching motility; and vi) specific binding to laminin and fibronectin. HCP are composed of a 19 kDa pilin subunit (HcpA) encoded by the hcpA chromosomal gene (called prepilin peptidase-dependent gene [ppdD] in E. coli K-12).
- Publication
PloS one, 2010, Vol 5, Issue 8, pe12127
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0012127