We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Low CD10 mRNA expression identifies high-risk ductal carcinoma in situ (DCIS).
- Authors
Toussaint, Jérôme; Durbecq, Virginie; Altintas, Sevilay; Doriath, Valérie; Rouas, Ghizlane; Paesmans, Marianne; Bedard, Philippe; Haibe-Kains, Benjamin; Tjalma, Wiebren A; Larsimont, Denis; Piccart, Martine; Sotiriou, Christos
- Abstract
Optimal management of breast ductal carcinoma in situ (DCIS) is controversial, and many patients are still overtreated. The local death of myoepithelial cells (MECs) is believed to be a pre-requisite to tumor invasion. We thus hypothesized that loss of CD10 expression, a MEC surface peptidase, would signify basement membrane disruption and confer increased risk of relapse in DCIS. The aim of our study was to retrospectively evaluate the prognostic value of CD10 in DCIS.
- Publication
PloS one, 2010, Vol 5, Issue 8
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0012100