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- Title
Sox6 is necessary for efficient erythropoiesis in adult mice under physiological and anemia-induced stress conditions.
- Authors
Dumitriu, Bogdan; Bhattaram, Pallavi; Dy, Peter; Huang, Yuanshuai; Quayum, Nayeem; Jensen, Jan; Lefebvre, Véronique
- Abstract
Definitive erythropoiesis is a vital process throughout life. Both its basal activity under physiological conditions and its increased activity under anemia-induced stress conditions are highly stimulated by the hormone erythropoietin. The transcription factor Sox6 was previously shown to enhance fetal erythropoiesis together and beyond erythropoietin signaling, but its importance in adulthood and mechanisms of action remain unknown. We used here Sox6 conditional null mice and molecular assays to address these questions.
- Publication
PloS one, 2010, Vol 5, Issue 8, pe12088
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0012088