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- Title
Exon-level transcriptome profiling in murine breast cancer reveals splicing changes specific to tumors with different metastatic abilities.
- Authors
Bemmo, Amandine; Dias, Christel; Rose, April A N; Russo, Caterina; Siegel, Peter; Majewski, Jacek
- Abstract
Breast cancer is the second most frequent type of cancer affecting women. We are increasingly aware that changes in mRNA splicing are associated with various characteristics of cancer. The most deadly aspect of cancer is metastasis, the process by which cancer spreads from the primary tumor to distant organs. However, little is known specifically about the involvement of alternative splicing in the formation of macroscopic metastases. Our study investigates transcript isoform changes that characterize tumors of different abilities to form growing metastases.
- Publication
PloS one, 2010, Vol 5, Issue 8, pe11981
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0011981