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- Title
Calcineurin interacts with PERK and dephosphorylates calnexin to relieve ER stress in mammals and frogs.
- Authors
Bollo, Mariana; Paredes, R Madelaine; Holstein, Deborah; Zheleznova, Nadezhda; Camacho, Patricia; Lechleiter, James D
- Abstract
The accumulation of misfolded proteins within the endoplasmic reticulum (ER) triggers a cellular process known as the Unfolded Protein Response (UPR). One of the earliest responses is the attenuation of protein translation. Little is known about the role that Ca2+ mobilization plays in the early UPR. Work from our group has shown that cytosolic phosphorylation of calnexin (CLNX) controls Ca2+ uptake into the ER via the sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) 2b.
- Publication
PloS one, 2010, Vol 5, Issue 8, pe11925
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0011925