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- Title
Structural comparison of human mammalian ste20-like kinases.
- Authors
Record, Christopher J; Chaikuad, Apirat; Rellos, Peter; Das, Sanjan; Pike, Ashley C W; Fedorov, Oleg; Marsden, Brian D; Knapp, Stefan; Lee, Wen Hwa
- Abstract
The serine/threonine mammalian Ste-20 like kinases (MSTs) are key regulators of apoptosis, cellular proliferation as well as polarization. Deregulation of MSTs has been associated with disease progression in prostate and colorectal cancer. The four human MSTs are regulated differently by C-terminal regions flanking the catalytic domains.
- Publication
PloS one, 2010, Vol 5, Issue 8, pe11905
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0011905