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- Title
Telomere-mediated chromosomal instability triggers TLR4 induced inflammation and death in mice.
- Authors
Bhattacharjee, Rabindra N; Banerjee, Birendranath; Akira, Shizuo; Hande, M Prakash
- Abstract
Telomeres are essential to maintain chromosomal stability. Cells derived from mice lacking telomerase RNA component (mTERC-/- mice) display elevated telomere-mediated chromosome instability. Age-dependent telomere shortening and associated chromosome instability reduce the capacity to respond to cellular stress occurring during inflammation and cancer. Inflammation is one of the important risk factors in cancer progression. Controlled innate immune responses mediated by Toll-like receptors (TLR) are required for host defense against infection. Our aim was to understand the role of chromosome/genome instability in the initiation and maintenance of inflammation.
- Publication
PloS one, 2010, Vol 5, Issue 7, pe11873
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0011873