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- Title
PR1-specific T cells are associated with unmaintained cytogenetic remission of chronic myelogenous leukemia after interferon withdrawal.
- Authors
Kanodia, Shreya; Wieder, Eric; Lu, Sijie; Talpaz, Moshe; Alatrash, Gheath; Clise-Dwyer, Karen; Molldrem, Jeffrey J
- Abstract
Interferon-alpha (IFN) induces complete cytogenetic remission (CCR) in 20-25% CML patients and in a small minority of patients; CCR persists after IFN is stopped. IFN induces CCR in part by increasing cytotoxic T lymphocytes (CTL) specific for PR1, the HLA-A2-restricted 9-mer peptide from proteinase 3 and neutrophil elastase, but it is unknown how CCR persists after IFN is stopped.
- Publication
PloS one, 2010, Vol 5, Issue 7, pe11770
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0011770