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- Title
Methylation of the tumor suppressor protein, BRCA1, influences its transcriptional cofactor function.
- Authors
Guendel, Irene; Carpio, Lawrence; Pedati, Caitlin; Schwartz, Arnold; Teal, Christine; Kashanchi, Fatah; Kehn-Hall, Kylene
- Abstract
Approximately half of hereditary breast cancers have mutations in either BRCA1 or BRCA2. BRCA1 is a multifaceted tumor suppressor protein that has implications in processes such as cell cycle, transcription, DNA damage response and chromatin remodeling. This multifunctional nature of BRCA1 is achieved by exerting its many effects through modulation of transcription. Many cellular events are dictated by covalent modification of proteins, an important mechanism in regulating protein and genome function; of which protein methylation is an important posttranslational modification with activating or repressive effects.
- Publication
PloS one, 2010, Vol 5, Issue 6, pe11379
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0011379