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- Title
Genetic loci involved in antibody response to Mycobacterium avium ssp. paratuberculosis in cattle.
- Authors
Minozzi, Giulietta; Buggiotti, Laura; Stella, Alessandra; Strozzi, Francesco; Luini, Mario; Williams, John L
- Abstract
Mycobacterium avium subsp. paratuberculosis (MAP) causes chronic enteritis in a wide range of animal species. In cattle, MAP causes a chronic disease called Johne's disease, or paratuberculosis, that is not treatable and the efficacy of vaccine control is controversial. The clinical phase of the disease is characterised by diarrhoea, weight loss, drop in milk production and eventually death. Susceptibility to MAP infection is heritable with heritability estimates ranging from 0.06 to 0.10. There have been several studies over the last few years that have identified genetic loci putatively associated with MAP susceptibility, however, with the availability of genome-wide high density SNP maker panels it is now possible to carry out association studies that have higher precision.
- Publication
PloS one, 2010, Vol 5, Issue 6, pe11117
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0011117