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- Title
Altered ratio of D1 and D2 dopamine receptors in mouse striatum is associated with behavioral sensitization to cocaine.
- Authors
Thompson, Dawn; Martini, Lene; Whistler, Jennifer L
- Abstract
Drugs of abuse elevate brain dopamine levels, and, in vivo, chronic drug use is accompanied by a selective decrease in dopamine D2 receptor (D2R) availability in the brain. Such a decrease consequently alters the ratio of D1R:D2R signaling towards the D1R. Despite a plethora of behavioral studies dedicated to the understanding of the role of dopamine in addiction, a molecular mechanism responsible for the downregulation of the D2R, in vivo, in response to chronic drug use has yet to be identified.
- Publication
PloS one, 2010, Vol 5, Issue 6, pe11038
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0011038