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- Title
Nucleic acid template and the risk of a PCR-Induced HIV-1 drug resistance mutation.
- Authors
Varghese, Vici; Wang, Elijah; Babrzadeh, Farbod; Bachmann, Michael H; Shahriar, Rajin; Liu, Tommy; Mappala, Svetlana Jean M; Gharizadeh, Baback; Fessel, W Jeffrey; Katzenstein, David; Kassaye, Seble; Shafer, Robert W
- Abstract
The HIV-1 nucleoside RT inhibitor (NRTI)-resistance mutation, K65R confers intermediate to high-level resistance to the NRTIs abacavir, didanosine, emtricitabine, lamivudine, and tenofovir; and low-level resistance to stavudine. Several lines of evidence suggest that K65R is more common in HIV-1 subtype C than subtype B viruses.
- Publication
PloS one, 2010, Vol 5, Issue 6, pe10992
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0010992