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- Title
Diazoxide promotes oligodendrocyte precursor cell proliferation and myelination.
- Authors
Fogal, Birgit; McClaskey, Carolyn; Yan, Sha; Yan, Henglin; Rivkees, Scott A
- Abstract
Several clinical conditions are associated with white matter injury, including periventricular white matter injury (PWMI), which is a form of brain injury sustained by preterm infants. It has been suggested that white matter injury in this condition is due to altered oligodendrocyte (OL) development or death, resulting in OL loss and hypomyelination. At present drugs are not available that stimulate OL proliferation and promote myelination. Evidence suggests that depolarizing stimuli reduces OL proliferation and differentiation, whereas agents that hyperpolarize OLs stimulate OL proliferation and differentiation. Considering that the drug diazoxide activates K(ATP) channels to hyperpolarize cells, we tested if this compound could influence OL proliferation and myelination.
- Publication
PloS one, 2010, Vol 5, Issue 5, pe10906
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0010906