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- Title
Molecular targeting of carbonic anhydrase IX in mice with hypoxic HT29 colorectal tumor xenografts.
- Authors
Carlin, Sean; Khan, Nahida; Ku, Thomas; Longo, Valerie A; Larson, Steve M; Smith-Jones, Peter M
- Abstract
Carbonic anhydrase IX (CAIX) is a membrane spanning protein involved in the enzymatic regulation of tumor acid-base balance. CAIX has been shown to be elevated in a number of hypoxic tumor types. The purpose of this study was to determine the efficiency of intact and IgG fragments of cG250 to target CAIX in vivo in a hypoxic tumor model.
- Publication
PloS one, 2010, Vol 5, Issue 5, pe10857
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0010857