We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma.
- Authors
Susa, Michiro; Iyer, Arun K; Ryu, Keinosuke; Choy, Edwin; Hornicek, Francis J; Mankin, Henry; Milane, Lara; Amiji, Mansoor M; Duan, Zhenfeng
- Abstract
The use of neo-adjuvant chemotherapy in treating osteosarcoma has improved patients' average 5 year survival rate from 20% to 70% in the past 30 years. However, for patients who progress after chemotherapy, its effectiveness diminishes due to the emergence of multi-drug resistance (MDR) after prolonged therapy.
- Publication
PloS one, 2010, Vol 5, Issue 5, pe10764
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0010764