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- Title
Discovery of high-affinity protein binding ligands--backwards.
- Authors
Diehnelt, Chris W; Shah, Miti; Gupta, Nidhi; Belcher, Paul E; Greving, Matthew P; Stafford, Phillip; Johnston, Stephen Albert
- Abstract
There is a pressing need for high-affinity protein binding ligands for all proteins in the human and other proteomes. Numerous groups are working to develop protein binding ligands but most approaches develop ligands using the same strategy in which a large library of structured ligands is screened against a protein target to identify a high-affinity ligand for the target. While this methodology generates high-affinity ligands for the target, it is generally an iterative process that can be difficult to adapt for the generation of ligands for large numbers of proteins.
- Publication
PloS one, 2010, Vol 5, Issue 5, pe10728
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0010728