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- Title
Calpain 4 is not necessary for LFA-1-mediated function in CD4+ T cells.
- Authors
Wernimont, Sarah A; Simonson, William T N; Greer, Peter A; Seroogy, Christine M; Huttenlocher, Anna
- Abstract
T cell activation and immune synapse formation require the appropriate activation and clustering of the integrin, LFA-1. Previous work has reported that the calpain family of calcium-dependent proteases are important regulators of integrin activation and modulate T cell adhesion and migration. However, these studies have been limited by the use of calpain inhibitors, which have known off-target effects.
- Publication
PloS one, 2010, Vol 5, Issue 5, pe10513
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0010513