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- Title
Biochemical characterization of enzyme fidelity of influenza A virus RNA polymerase complex.
- Authors
Aggarwal, Shilpa; Bradel-Tretheway, Birgit; Takimoto, Toru; Dewhurst, Stephen; Kim, Baek
- Abstract
It is widely accepted that the highly error prone replication process of influenza A virus (IAV), together with viral genome assortment, facilitates the efficient evolutionary capacity of IAV. Therefore, it has been logically assumed that the enzyme responsible for viral RNA replication process, influenza virus type A RNA polymerase (IAV Pol), is a highly error-prone polymerase which provides the genomic mutations necessary for viral evolution and host adaptation. Importantly, however, the actual enzyme fidelity of IAV RNA polymerase has never been characterized.
- Publication
PloS one, 2010, Vol 5, Issue 4, pe10372
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0010372