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- Title
Calpain3 is expressed in a proteolitically active form in papillomavirus-associated urothelial tumors of the urinary bladder in cattle.
- Authors
Roperto, Sante; De Tullio, Roberta; Raso, Cinzia; Stifanese, Roberto; Russo, Valeria; Gaspari, Marco; Borzacchiello, Giuseppe; Averna, Monica; Paciello, Orlando; Cuda, Gianni; Roperto, Franco
- Abstract
Calpain 3 (Capn3), also named p94, is a skeletal muscle tissue-specific protein known to be responsible for limb-girdle muscular dystrophy type 2A (LGMD2A). Recent experimental studies have hypothesized a pro-apoptotic role of Capn3 in some melanoma cell lines. So far the link between calpain3 and tumors comes from in vitro studies. The objective of this study was to describe Capn3 activation in naturally occurring urothelial tumors of the urinary bladder in cattle.
- Publication
PloS one, 2010, Vol 5, Issue 4, pe10299
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0010299