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- Title
A defined and xeno-free culture method enabling the establishment of clinical-grade human embryonic, induced pluripotent and adipose stem cells.
- Authors
Rajala, Kristiina; Lindroos, Bettina; Hussein, Samer M; Lappalainen, Riikka S; Pekkanen-Mattila, Mari; Inzunza, Jose; Rozell, Björn; Miettinen, Susanna; Narkilahti, Susanna; Kerkelä, Erja; Aalto-Setälä, Katriina; Otonkoski, Timo; Suuronen, Riitta; Hovatta, Outi; Skottman, Heli
- Abstract
The growth of stem cells in in vitro conditions requires optimal balance between signals mediating cell survival, proliferation, and self-renewal. For clinical application of stem cells, the use of completely defined conditions and elimination of all animal-derived materials from the establishment, culture, and differentiation processes is desirable.
- Publication
PloS one, 2010, Vol 5, Issue 4, pe10246
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0010246