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- Title
Hemolysis is associated with low reticulocyte production index and predicts blood transfusion in severe malarial anemia.
- Authors
Fendel, Rolf; Brandts, Christian; Rudat, Annika; Kreidenweiss, Andrea; Steur, Claudia; Appelmann, Iris; Ruehe, Bettina; Schröder, Paul; Berdel, Wolfgang E; Kremsner, Peter G; Mordmüller, Benjamin
- Abstract
Falciparum Malaria, an infectious disease caused by the apicomplexan parasite Plasmodium falciparum, is among the leading causes of death and morbidity attributable to infectious diseases worldwide. In Gabon, Central Africa, one out of four inpatients have severe malarial anemia (SMA), a life-threatening complication if left untreated. Emerging drug resistant parasites might aggravate the situation. This case control study investigates biomarkers of enhanced hemolysis in hospitalized children with either SMA or mild malaria (MM).
- Publication
PloS one, 2010, Vol 5, Issue 4, pe10038
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0010038