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- Title
The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide.
- Authors
Soscia, Stephanie J; Kirby, James E; Washicosky, Kevin J; Tucker, Stephanie M; Ingelsson, Martin; Hyman, Bradley; Burton, Mark A; Goldstein, Lee E; Duong, Scott; Tanzi, Rudolph E; Moir, Robert D
- Abstract
The amyloid beta-protein (Abeta) is believed to be the key mediator of Alzheimer's disease (AD) pathology. Abeta is most often characterized as an incidental catabolic byproduct that lacks a normal physiological role. However, Abeta has been shown to be a specific ligand for a number of different receptors and other molecules, transported by complex trafficking pathways, modulated in response to a variety of environmental stressors, and able to induce pro-inflammatory activities.
- Publication
PloS one, 2010, Vol 5, Issue 3, pe9505
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0009505