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- Title
Changes in clinical trials methodology over time: a systematic review of six decades of research in psychopharmacology.
- Authors
Brunoni, André R; Tadini, Laura; Fregni, Felipe
- Abstract
There have been many changes in clinical trials methodology since the introduction of lithium and the beginning of the modern era of psychopharmacology in 1949. The nature and importance of these changes have not been fully addressed to date. As methodological flaws in trials can lead to false-negative or false-positive results, the objective of our study was to evaluate the impact of methodological changes in psychopharmacology clinical research over the past 60 years.
- Publication
PloS one, 2010, Vol 5, Issue 3, pe9479
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0009479