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- Title
A computational approach for deciphering the organization of glycosaminoglycans.
- Authors
Spencer, Jean L; Bernanke, Joel A; Buczek-Thomas, Jo Ann; Nugent, Matthew A
- Abstract
Increasing evidence has revealed important roles for complex glycans as mediators of normal and pathological processes. Glycosaminoglycans are a class of glycans that bind and regulate the function of a wide array of proteins at the cell-extracellular matrix interface. The specific sequence and chemical organization of these polymers likely define function; however, identification of the structure-function relationships of glycosaminoglycans has been met with challenges associated with the unique level of complexity and the nontemplate-driven biosynthesis of these biopolymers.
- Publication
PloS one, 2010, Vol 5, Issue 2, pe9389
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0009389