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- Title
PACAP-deficient mice exhibit light parameter-dependent abnormalities on nonvisual photoreception and early activity onset.
- Authors
Kawaguchi, Chihiro; Isojima, Yasushi; Shintani, Norihito; Hatanaka, Michiyoshi; Guo, Xiaohong; Okumura, Nobuaki; Nagai, Katsuya; Hashimoto, Hitoshi; Baba, Akemichi
- Abstract
The photopigment melanopsin has been suggested to act as a dominant photoreceptor in nonvisual photoreception including resetting of the circadian clock (entrainment), direct tuning or masking of vital status (activity, sleep/wake cycles, etc.), and the pupillary light reflex (PLR). Pituitary adenylate cyclase-activating polypeptide (PACAP) is exclusively coexpressed with melanopsin in a small subset of retinal ganglion cells and is predicted to be involved extensively in these responses; however, there were inconsistencies in the previous reports, and its functional role has not been well understood.
- Publication
PloS one, 2010, Vol 5, Issue 2, pe9286
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0009286