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- Title
Raptor is phosphorylated by cdc2 during mitosis.
- Authors
Gwinn, Dana M; Asara, John M; Shaw, Reuben J
- Abstract
The appropriate control of mitotic entry and exit is reliant on a series of interlocking signaling events that coordinately drive the biological processes required for accurate cell division. Overlaid onto these signals that promote orchestrated cell division are checkpoints that ensure appropriate mitotic spindle formation, a lack of DNA damage, kinetochore attachment, and that each daughter cell has the appropriate complement of DNA. We recently discovered that AMP-activated protein kinase (AMPK) modulates the G2/M phase of cell cycle progression in part through its suppression of mammalian target of rapamycin (mTOR) signaling. AMPK directly phosphorylates the critical mTOR binding partner raptor inhibiting mTORC1 (mTOR-raptor rapamycin sensitive mTOR kinase complex 1). As mTOR has been previously tied to mitotic control, we examined further how raptor may contribute to this process.
- Publication
PloS one, 2010, Vol 5, Issue 2, pe9197
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0009197