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- Title
Strain background modifies phenotypes in the ATP8B1-deficient mouse.
- Authors
Shah, Sohela; Sanford, Ukina R; Vargas, Julie C; Xu, Hongmei; Groen, Annamiek; Paulusma, Coen C; Grenert, James P; Pawlikowska, Ludmila; Sen, Saunak; Elferink, Ronald P J Oude; Bull, Laura N
- Abstract
Mutations in ATP8B1 (FIC1) underlie cases of cholestatic disease, ranging from chronic and progressive (progressive familial intrahepatic cholestasis) to intermittent (benign recurrent intrahepatic cholestasis). The ATP8B1-deficient mouse serves as an animal model of human ATP8B1 deficiency.
- Publication
PloS one, 2010, Vol 5, Issue 2, pe8984
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0008984