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- Title
CBL is frequently altered in lung cancers: its relationship to mutations in MET and EGFR tyrosine kinases.
- Authors
Tan, Yi-Hung Carol; Krishnaswamy, Soundararajan; Nandi, Suvobroto; Kanteti, Rajani; Vora, Sapana; Onel, Kenan; Hasina, Rifat; Lo, Fang-Yi; El-Hashani, Essam; Cervantes, Gustavo; Robinson, Matthew; Hsu, Han-Shui; Kales, Stephen C; Lipkowitz, Stanley; Karrison, Theodore; Sattler, Martin; Vokes, Everett E; Wang, Yi-Ching; Salgia, Ravi
- Abstract
Non-small cell lung cancer (NSCLC) is a heterogeneous group of disorders with a number of genetic and proteomic alterations. c-CBL is an E3 ubiquitin ligase and adaptor molecule important in normal homeostasis and cancer. We determined the genetic variations of c-CBL, relationship to receptor tyrosine kinases (EGFR and MET), and functionality in NSCLC.
- Publication
PloS one, 2010, Vol 5, Issue 1, pe8972
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0008972