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- Title
Time-resolved and tissue-specific systems analysis of the pathogenesis of insulin resistance.
- Authors
Kleemann, Robert; van Erk, Marjan; Verschuren, Lars; van den Hoek, Anita M; Koek, Maud; Wielinga, Peter Y; Jie, Annie; Pellis, Linette; Bobeldijk-Pastorova, Ivana; Kelder, Thomas; Toet, Karin; Wopereis, Suzan; Cnubben, Nicole; Evelo, Chris; van Ommen, Ben; Kooistra, Teake
- Abstract
The sequence of events leading to the development of insulin resistance (IR) as well as the underlying pathophysiological mechanisms are incompletely understood. As reductionist approaches have been largely unsuccessful in providing an understanding of the pathogenesis of IR, there is a need for an integrative, time-resolved approach to elucidate the development of the disease.
- Publication
PloS one, 2010, Vol 5, Issue 1, pe8817
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0008817