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- Title
Biomarkers of endocannabinoid system activation in severe obesity.
- Authors
Sipe, Jack C; Scott, T Michael; Murray, Sarah; Harismendy, Olivier; Simon, Gabriel M; Cravatt, Benjamin F; Waalen, Jill
- Abstract
Obesity is a worldwide epidemic, and severe obesity is a risk factor for many diseases, including diabetes, heart disease, stroke, and some cancers. Endocannabinoid system (ECS) signaling in the brain and peripheral tissues is activated in obesity and plays a role in the regulation of body weight. The main research question here was whether quantitative measurement of plasma endocannabinoids, anandamide, and related N-acylethanolamines (NAEs), combined with genotyping for mutations in fatty acid amide hydrolase (FAAH) would identify circulating biomarkers of ECS activation in severe obesity.
- Publication
PloS one, 2010, Vol 5, Issue 1, pe8792
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0008792