We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Endogenous morphine levels are increased in sepsis: a partial implication of neutrophils.
- Authors
Glattard, Elise; Welters, Ingeborg D; Lavaux, Thomas; Muller, Arnaud H; Laux, Alexis; Zhang, Dan; Schmidt, Alexander R; Delalande, François; Laventie, Benoît-Joseph; Dirrig-Grosch, Sylvie; Colin, Didier A; Van Dorsselaer, Alain; Aunis, Dominique; Metz-Boutigue, Marie-Hélène; Schneider, Francis; Goumon, Yannick
- Abstract
Mammalian cells synthesize morphine and the respective biosynthetic pathway has been elucidated. Human neutrophils release this alkaloid into the media after exposure to morphine precursors. However, the exact role of endogenous morphine in inflammatory processes remains unclear. We postulate that morphine is released during infection and can be determined in the serum of patients with severe infection such as sepsis.
- Publication
PloS one, 2010, Vol 5, Issue 1, pe8791
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0008791