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- Title
Glycemic control promotes pancreatic beta-cell regeneration in streptozotocin-induced diabetic mice.
- Authors
Grossman, Eric J; Lee, David D; Tao, Jing; Wilson, Raphael A; Park, Soo-Young; Bell, Graeme I; Chong, Anita S
- Abstract
Pancreatic beta-cells proliferate following administration of the beta-cell toxin streptozotocin. Defining the conditions that promote beta-cell proliferation could benefit patients with diabetes. We have investigated the effect of insulin treatment on pancreatic beta-cell regeneration in streptozotocin-induced diabetic mice, and, in addition, report on a new approach to quantify beta-cell regeneration in vivo.
- Publication
PloS one, 2010, Vol 5, Issue 1, pe8749
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0008749