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Title
Sonic Hedgehog gene delivery to the rodent heart promotes angiogenesis via iNOS/netrin-1/PKC pathway.
Authors
Ahmed, Rafeeq P H; Haider, Khawaja Husnain; Shujia, Jiang; Afzal, Muhammad Rizwan; Ashraf, Muhammad
Abstract
We hypothesized that genetic modification of mesenchymal stem cells (MSCs) with Sonic Hedgehog (Shh) transgene, a morphogen during embryonic development and embryonic and adult stem cell growth, improved their survival and angiogenic potential in the ischemic heart via iNOS/netrin/PKC pathway.