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- Title
High throughput sequencing and proteomics to identify immunogenic proteins of a new pathogen: the dirty genome approach.
- Authors
Greub, Gilbert; Kebbi-Beghdadi, Carole; Bertelli, Claire; Collyn, François; Riederer, Beat M; Yersin, Camille; Croxatto, Antony; Raoult, Didier
- Abstract
With the availability of new generation sequencing technologies, bacterial genome projects have undergone a major boost. Still, chromosome completion needs a costly and time-consuming gap closure, especially when containing highly repetitive elements. However, incomplete genome data may be sufficiently informative to derive the pursued information. For emerging pathogens, i.e. newly identified pathogens, lack of release of genome data during gap closure stage is clearly medically counterproductive.
- Publication
PloS one, 2009, Vol 4, Issue 12, pe8423
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0008423