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- Title
Induction of ovarian leiomyosarcomas in mice by conditional inactivation of Brca1 and p53.
- Authors
Quinn, Bridget A; Brake, Tiffany; Hua, Xiang; Baxter-Jones, Kimberly; Litwin, Samuel; Ellenson, Lora Hedrick; Connolly, Denise C
- Abstract
Approximately one out of every ten cases of epithelial ovarian cancer (EOC) is inherited. The majority of inherited cases of EOC result from mutations in the breast cancer associated gene 1 (BRCA1). In addition to mutation of BRCA1, mutation of the p53 gene is often found in patients with inherited breast and ovarian cancer syndrome.
- Publication
PloS one, 2009, Vol 4, Issue 12, pe8404
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0008404