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Title
Effect of leucovorin (folinic acid) on the developmental quotient of children with Down's syndrome (trisomy 21) and influence of thyroid status.
Authors
Blehaut, Henri; Mircher, Clotilde; Ravel, Aimé; Conte, Martine; de Portzamparc, Veronique; Poret, Gwendael; de Kermadec, Françoise Huon; Rethore, Marie-Odile; Sturtz, Franck G
Abstract
Seven genes involved in folate metabolism are located on chromosome 21. Previous studies have shown that folate deficiency may contribute to mental retardation in Down's syndrome (DS).