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- Title
RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans.
- Authors
Sebastiani, Paola; Montano, Monty; Puca, Annibale; Solovieff, Nadia; Kojima, Toshio; Wang, Meng C; Melista, Efthymia; Meltzer, Micah; Fischer, Sylvia E J; Andersen, Stacy; Hartley, Stephen H; Sedgewick, Amanda; Arai, Yasumichi; Bergman, Aviv; Barzilai, Nir; Terry, Dellara F; Riva, Alberto; Anselmi, Chiara Viviani; Malovini, Alberto; Kitamoto, Aya; Sawabe, Motoji; Arai, Tomio; Gondo, Yasuyuki; Steinberg, Martin H; Hirose, Nobuyoshi; Atzmon, Gil; Ruvkun, Gary; Baldwin, Clinton T; Perls, Thomas T
- Abstract
The strong familiality of living to extreme ages suggests that human longevity is genetically regulated. The majority of genes found thus far to be associated with longevity primarily function in lipoprotein metabolism and insulin/IGF-1 signaling. There are likely many more genetic modifiers of human longevity that remain to be discovered.
- Publication
PloS one, 2009, Vol 4, Issue 12, pe8210
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0008210